Phytochemical Analysis and Antifungal Activity of Brunei Propolis Against Candida sp. and Cryptococcus sp.

The propolis used in this study is from Brunei Darussalam, including G. thoracica, H. itama, and T. binghami. This focuses on evaluating phytochemicals, the total content of polyphenols flavonoids, marker compounds, anti-fungal activity Brunei. Until now, research compounds contained still being carried out. However, literature chemical compound limited. results using LC-MS/MS found as many 21 three namely maslinic acid, D-(-) Mannitol, 18-?-Glycyrrhetinic acid. flavonoid polyphenolic was obtained quercetin a standard gallic acid polyphenol standard. In propolis, higher than content. Where binghami were 78.79±17.06; 70.51±12.93 16.37±0.53 (mgGAE/g). while 19.30±1.99; 101.10±6.26 61.63±4.53 (mg QE/g). antifungal out by agar diffusion microdilution methods. extract showed against Cryptococcus C. Albicans, whereas with intermediate resistance to both fungi.